21 Night Cruise sailing from New Orleans to St Paul aboard American Harmony.
Relax and enjoy the passing landscapes as we make our way along the Mississippi River from New Orleans, LA to St. Paul, MN. As you visit 10 states in 22 days, experience life as it once was on the western frontier.
Starting in Lower Mississippi, explore southern plantations, stately antebellum houses, and Civil War battlefields. In Memphis, known for Blues and Barbeque, immerse yourself in the rich culture of one of the Mid-South's most vibrant cities.
After cruising past the Gateway Arch Riverfront in St. Louis, journey to Hannibal, the hometown of the famous author Mark Twain, where the characters of Huck Finn, Tom Sawyer, and Becky Thatcher come to life. Traveling up the river, get up-close views of bald eagle nests, beaver lodges, and great blue herons, from the comfort of your furnished private balcony.
Day 1 New Orleans, LA
New Orleans is commonly referred to as the birthplace of Jazz. There is something for everyone in this historic city where art and culture prevail. The open-air artist colony proudly displays local works on the iron fence in Jackson Square, while the city’s 45 museums carefully preserve its past. Consider staying an extra day or night to enjoy this lively city.
Day 2 Oak Alley, LA
Once serving as an antebellum sugar cane plantation, Oak Alley Plantation is rightfully named after its most distinguishing feature, a canopy of 300-year-old oak trees that form a quarter-mile path leading to the Mississippi River. Restored to its 19th-century grandeur, this classic Greek Revival-style antebellum mansion is simply breathtaking.
Day 3 Houmas House, LA
The historic Houmas House takes you back to the pre-Civil War era of stately mansions and expansive plantations. Featuring over 38 acres of lush gardens, ponds, and ancient oak trees, this shore excursion is rich in beauty and history. Enduring floods, war, and the Great Depression, Houmas House underwent a renovation in 1940 and today offers a detailed look into the legacy of the South.
Day 4 Baton Rouge, LA
Experience the wonder of Baton Rouge, Louisiana's capital, and one of the most historic and unforgettable cities in the South. Known as the Red Stick, Baton Rouge has everything you would expect to find in a state capital, but with a down-home flavor that is part of its charm.
Day 5 St. Francisville, LA
Established in 1809, St. Francisville is a quaint southern town overlooking the Mississippi River. One of the largest shipping ports on the Mississippi River prior to the Civil War, St. Francisville is a small town with grand appeal. Experience the town’s rich history as you tour historic plantations, including the famous Rosedown, or explore the areas' captivating gardens.
Day 6 Natchez, MS
Perched on a bluff above the Mississippi River, Natchez is a city 300 years in the making. Over a thousand of its buildings are listed on the National Register of Historic Places. Upon closer inspection, you will soon discover that Natchez, while indeed a reflection of the past, is also alive in the present, filled with art, music, culture, and commerce.
Day 7 Vicksburg, MS
U.S. history is alive in Vicksburg. This “Queen City of the Bluff” offers plenty of opportunities to take a step back in time. Civil War battlefields, century-old churches, cotton fields, and restored train depots are just a few of the many intriguing landmarks that await your visit. Marvel in the beautiful antebellum-style homes and learn about Vicksburg’s rich history as displayed on the riverfront murals.
Day 8 Greenville, MS
Known as the Heart and Soul of the Mississippi Delta, the city of Greenville offers visitors unique insight into traditional southern living. Enjoy a relaxing trip through the historic sites of the largest city in Mississippi, including Cotton Row, the Mount Holly Plantation, and the Weatherbee House.
Day 9 Memphis, TN
Excitement resonates as you reach America’s third-largest inland port, famous for Blues, BBQ, and Elvis Presley's Graceland. The Memphis-Arkansas Memorial Bridge creates a dramatic backdrop for one of the most remarkable cities in the mid-South.
Day 10 New Madrid, MO
Originally founded in 1776 by Spanish Governor Esteban Rodriguez, early settlers of New Madrid were required to become citizens of Spain in order to reside here. Today, New Madrid is a living monument to early American history with sites including the Kochtitsky Home, the Trail of Tears, and Veterans Park.
Day 11 Cape Girardeau, MO
Enjoy the charming features of this historic town that was a French trading post and lively river port in the late 1800s. Today it boasts Civil War sites and a tranquil setting commemorating the Cherokee Trail of Tears. Marvel at the outdoor murals reflecting the area's rich heritage and enjoy shore excursions to Crisp Museum and the Old Vincent Church.
Day 12 Chester, IL
Chester is a beautiful region of Illinois located on the bluffs of the Mississippi River, with a diverse and storied history. Chester is also home to Popeye's creator Elzie C. Segar; you may see the sailor man's likeness in the town's six-foot-tall bronze metal statue.
Day 13 St. Louis, MO
St. Louis is often referred to as the “Gateway to the West.” Take in the Gateway Arch Riverfront, highlighted by the Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis' many world-class attractions, including the Art Museum, Science Center, Anheuser-Busch Brewery, and the Missouri History Museum. End your day by relaxing at the Missouri Botanical Garden, one of the world’s most popular public gardens.
Day 14 Day of River Cruising
Curl up with a good book in one of our spacious lounges. Or relax on the sun deck and enjoy the passing landscapes as we make our way along the Mississippi River from St. Louis to Hannibal.
Day 15 Hannibal, MO
Discover Hannibal, “America’s Hometown,” and the inspiration behind many of Mark Twain’s literary characters. Tom Sawyer and Huck Finn come to life in this charming Missouri town, where you can run your hand along Aunt Polly’s fence, explore Injun Joe’s Cave, and get reacquainted with one of the world’s most beloved authors. The downtown area is a thriving haven for artisans, filled with specialty shops unique to Hannibal.
Day 16 Day of River Cruising
Listen to onboard experts sharing their knowledge of the history of our nation and the river, as we cruise between the borders of Missouri and Iowa.
Day 17 Davenport, IA
Davenport is often described as a lively place with a hometown feel. The Legacy of John Deere, the largest agricultural exhibit in the world, takes place here. Music enthusiasts will enjoy Davenport’s many music festivals, including the Mississippi Valley Blues Festival, The Mississippi Valley Fair, and the Bix Beiderbecke Memorial Jazz Festival, which is dedicated to native Jazz musician Bix Beiderbecke.
Day 18 Dubuque, IA
Dubuque is among the oldest settlements west of the Mississippi River. Take a ride on the Fenelon Place Elevator, the world’s shortest and steepest scenic railway or try your luck in one of Dubuque's state-of-the-art casinos. View colorful Victorian mansions, stroll through a whimsical downtown area, and visit the National Mississippi River Museum & Aquarium.
Day 19 Day of River Cruising
Reflect on the incredible journey you have experienced so far and get ready for the final leg of the trip, cruising the Upper Mississippi River.
Day 20 La Crosse, WI
Step into 19th-century America in La Crosse, located on the banks of three captivating rivers. La Crosse is home to Riverside Park, where you can enjoy beautiful gardens and inspiring sculptures.
Day 21 Red Wing, MN
Nestled among the scenic bluffs of the Upper Mississippi River, Red Wing's beauty has inspired craftsmen and artisans for over 150 years. Red Wing offers a diverse blend of arts, entertainment, and activities. Enjoy a show at the historic Sheldon Performing Arts Theatre or observe the beauty of nature at one of Red Wing’s 38 parks.
Day 22 St. Paul, MN
St. Paul is an exciting place to end your adventure on the Mississippi River. History buffs will enjoy a walking tour of Summit Avenue, which showcases gorgeous historic mansions built in the late 1800’s. St. Paul’s enchanting art galleries, world-class museums, and entertaining stage performances will capture your imagination. End the day by visiting Mounds Park, where visitors are treated to a beautiful panoramic view of the city.
Please note, while prices and inclusions are accurate at time of loading they are subject to change due to changes in cruise line policies and pricing and due to currency fluctuations. Currency surcharges may apply. Please check details of price and inclusions at time of booking.